Esketamine can trigger some initial and short-lived side effects such as dizziness, floating sensations, or mild dissociation. Dissociation includes the most common psychological effects of Spravato, which have been dissociative/perceptual changes (including distortion of time and space, and illusions), derealization, and depersonalization. Patients may describe these symptoms as feeling disconnected from themselves, their thoughts and feelings, space, and time. You will be under the supervision of a member of our clinical team for approximately two hours to ensure timely care in case of adverse effects occur. When your provider releases you, you will need a friend or family member to drive you home. You may be tired for the rest of the day, but any fatigue will pass by the time you wake up the next morning.